Evidence-based, rigorous, relevant and up-to-date research is vital to the public policymaking process; it enhances the effectiveness and efficiency of policy decisions. This article reflects on the nature of demand for such research in the South Asian region and contends that though the quantity and quality of evidence and knowledge for policy research is important, it is equally important to assess the factors that affect its demand.Hence, the preferences and requirements of the policymaking community should be taken cognisance of, otherwise the uptake and use of evidence and knowledge in policymaking would be impeded.